蓝莓水对慢性压力下大鼠认知功能障碍的保护作用
G Qian 黎黍匀
（韩国中央大学营养系，韩国京畿道安城；广西南宁上古智阳公司，530001）`
【摘要】研究目的：通过对成年大鼠为期8周的蓝莓水补充，观察对其处于慢性心理压力作用下的认知能力的影响作用。方法：12周龄的雄性SD大鼠随机分为四组（n=12/组）。实验期结束后，通过水迷宫测试对大鼠的认知水平进行了评估。结果：水迷宫结果显示，+STR组（压力组）的认知能力较对照组显著降低，而补充蓝莓水的组对此变化有明显改善（P<0.05）；与+STR组相比，蓝莓水显著提高了大鼠脑组织中SOD、GSH-PX活性和抗坏血酸含量，并明显增加了血浆中去甲肾上腺素和多巴胺的水平（P<0.05）。结论：实验结果显示，蓝莓水能够有效防止慢性心理压力引起的认知功能障碍。
【关键词】 蓝莓；慢性心理压力；认知功能障碍；水迷宫
Protective Effects of Blueberry Drink on Cognitive Impairments Induced by Chronic
Psychological Stress in Rats,G qian,LI shu-yun.( Department of Food and Nutrition, University of Chung-Ang, Anseong, Gyeonggi-do,Korea. Nanning Shanggu Zhiyang Nutrition Consultation Co. Ltd., 530001,China)
Abstract: Obiective The aim of this study was to investigate the effect of 8-week supplementation of blueberry drink on the cognitive performance of adult rats exposed to chronic psychological stress. Methods Three month-old male Sprague–Dawley rats were randomly divided into four groups. At the end of experimental period, the evaluation of rodent cognitive level was assessed by a water maze test. Results The cognitive performances of the +STR group were impaired evidently as compared to those of the CON group, and these changes were improved significantly by BB drink supplementation (P<0.05). The administration of BB drink also resulted in higher brain SOD, GSH-Px, and ascorbic acid levels, and increased plasma norepinephrine and dopamine levels than the +STR group significantly (P<0.05). Conclusions These findings suggest that blueberry drink may protect against cognitive impairment induced by chronic psychological stress.
Keywords: Blueberry(BB); Chronic Psychological Stress；Cognitive Impairment；Water maze
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